Pioneering the discovery and development of novel medicines and devices.

Technology

Lamellasomes™ are multilamellar vesicles comprising of phospholipids and cholesterol designed to mimic the structure, composition and function of lamellar bodies [Figure 2]. 

The in vitro screening of a library of analogues has yielded Lamellasomes™ with the ability:

  • To alter the biophysical properties of biological gels such as fibrin, DNA, alginate, mucin, sebum, cerumen, blood clots and ex-vivo sputum from patients with cystic fibrosis.
  • To adsorb pro-inflammatory markers and active drug substances.
  • To be avidly ingested by dendritic cells.
  • To be recognised as "self" by the immune system
  • To potentiate antibiotics
  • To disrupt bacterial biofilms
     
[Figure 2]
An electron micrograph of a Lamellasome™ fixed in glutaraldehyde/tannic acid mixture, displaying tightly-packed concentric lamellae with identical Dupin cyclides geometry to that found in naturally-occurring lamellar bodies.
     [Figure 3]
The spontaneous and dynamic mixing of a droplet of the Lamellasome, LMS-611 (left-hand droplet) on contact with a droplet of mucus (right-hand droplet), as seen under light microscopy.