Technology

Lamellasomes™ are multilamellar vesicles comprising of phospholipids and cholesterol designed to mimic the structure, composition and function of lamellar bodies [Figure 2].

The in vitro screening of a library of analogues has yielded Lamellasomes™ with the ability:

To alter the biophysical properties of biological gels such as fibrin, DNA, alginate, mucin, sebum, cerumen, blood clots and ex-vivo sputum from patients with cystic fibrosis.
To adsorb pro-inflammatory markers and active drug substances.
To be avidly ingested by dendritic cells.
To be recognised as "self" by the immune system
To potentiate antibiotics
To disrupt bacterial biofilms

[Figure 2]
An electron micrograph of a Lamellasome™ fixed in glutaraldehyde/tannic acid mixture, displaying tightly-packed concentric lamellae with identical Dupin cyclides geometry to that found in naturally-occurring lamellar bodies.

[Figure 3]
The spontaneous and dynamic mixing of a droplet of the Lamellasome, LMS-611 (left-hand droplet) on contact with a droplet of mucus (right-hand droplet), as seen under light microscopy.